Each episode begins with MIO and MAO rolling and tumbling across a fantastic world of clay accompanied by their charming music tune: "Mio, Mao, la la la la la...". While doing so their attention is drawn by some strange sound, but what is it? Their curiosity leads them to watch from the distance: It is a mysterious moving shape. Both kitties get closer to look. The mysterious shape finally reveals itself, it's only a friendly animal to play with.